Sarcopenia is the muscle atrophy associated with aging and can be slowed by exercise. Exercise is one of the key strategies to prevent and treat various diseases. Please enable it to take advantage of the complete set of features! Functional and morphological effects of resistance exercise on disuse-induced skeletal muscle atrophy. Reduction in physical activity leads to muscle loss within 72 hours. Br Med J 290(6476):1163–1164, Nikander R, Sievänen H, Heinonen A, Daly RM, Uusirasi K, Kannus P (2010) Targeted exercise against osteoporosis: a systematic review and meta-analysis for optimising bone strength throughout life. It is a public health issue that causes a growing concern around the world. Am Phys Soc J 268(2 Pt 1):E268–E276, Jurasinski G, Vary TC (1995) Modulation of skeletal muscle protein synthesis by amino acids and insulin during sepsis. Acta Physiol 167(1):57–68, Ballak SB, Degens H, de Haan A, Jaspers RT (2014) Aging related changes in determinants of muscle force generating capacity: a comparison of muscle aging in men and male rodents. Diabetes Care 33(12):e147–e167, Association AD (2000) Diabetes mellitus and exercise. Skeletal muscle mitochondria: a major player in exercise, health and disease. Mayo Clin Proc 50(11):621–637, Abrahams S, Leigh PN, Harvey A, Vythelingum GN, Grisé D, Goldstein LH (2000) Verbal fluency and executive dysfunction in amyotrophic lateral sclerosis (ALS). Lancet Neurol 2(12):731–740, Kang PB, Griggs RC (2015) Advances in muscular dystrophies. BMC Med 8(1):47, © Springer Nature Singapore Pte Ltd. 2020, Department of Cardiology, Huamei Hospital, (previously named Ningbo No. Autophagy 4(3):378–380, Chen YW, Gregory CM, Scarborough MT, Shi R, Walter GA, Vandenborne K (2007) Transcriptional pathways associated with skeletal muscle disuse atrophy in humans. Exercise and Muscle Atrophy. Metab Clin Exp 44(9):1130–1138, Tuffaha SH, Budihardjo JD, Sarhane KA, Khusheim M, Song D, Broyles JM, Salvatori R, Means KR Jr, Higgins JP, Shores JT, Cooney DS, Hoke A, Lee WP, Brandacher G (2016) Growth hormone therapy accelerates axonal regeneration, promotes motor reinnervation, and reduces muscle atrophy following peripheral nerve injury. Curr Opin Support Palliat Care 8(4):321–327, Gleeson M, Bishop NC, Stensel DJ, Lindley MR, Mastana SS, Nimmo MA (2011) The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Nat Rev Immunol 11(9):607–615, Betof AS, Dewhirst MW, Jones LW (2013) Effects and potential mechanisms of exercise training on cancer progression: a translational perspective. HHS J Appl Physiol 88(1):359–363, Lecker SH, Jagoe RT, Gilbert A, Gomes M, Baracos V, Bailey J, Price SR, Mitch WE, Goldberg AL (2004) Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression. Am J Physiol Endocrinol Metab 309(6):E557–E567, Giustina A, Mazziotti G, Canalis E (2008) Growth hormone, insulin-like growth factors, and the skeleton. Int J Mol Med 38(3):845–852, Park YM, Pereira RI, Erickson CB, Swibas TA, Kang CH, Van Pelt RE (2017) Time since menopause and skeletal muscle estrogen receptors, PGC-1 alpha, and AMPK. ALS/Riluzole study group. 2 Hospital), University of Chinese Academy of Sciences, Department of Experimental Medical Science, HwaMei Hospital, Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province, https://doi.org/10.1007/978-981-15-1792-1_17, Advances in Experimental Medicine and Biology. J Gerontol Ser A Biol Sci Med Sci 52(5):B267–B276, Izquierdo M, Ibañez J, Gorostiaga E, Garrues M, Zúñiga A, Antón A, Larrión JL, Häkkinen K (2010) Maximal strength and power characteristics in isometric and dynamic actions of the upper and lower extremities in middle-aged and older men. HHS Nephrol Dial Transplant 13(3):685–699, Bassil MS, Gougeon R (2013) Muscle protein anabolism in type 2 diabetes.