We assessed PSMD in relation to conventional SVD markers, global measures of neurodegeneration, and cognition. The ageing process alters the human brain, leading to modifications to its organised modularity and these changes are further accentuated by neurodegeneration, leading to disorganisation. We used a magnetic resonance imaging segmentation tool to quantify multiple types of small vessel disease-related brain changes and examined their individual and combined predictive value on cognitive and functional abilities. We review the frequency and pathogenesis of visual hallucinations in dementia and Parkinson’s disease and examine the evidence base for their... Inflammation is increasingly recognized as part of the pathology of neurodegenerative conditions such as Alzheimer's disease and Parkinson's disease, but its role in dementia with Lewy bodies remains unclear. John O'BRIEN, Professor of Old Age Psychiatry of University of Cambridge, Cambridge (Cam) | Read 893 publications | Contact John O'BRIEN Uncertainties remain whether there is a single underlying mechanism for visual hallucinations or they have different disease-dependent causes. University students and faculty, institute members, and independent researchers, Technology or product developers, R&D specialists, and government or NGO employees in scientific roles, Health care professionals, including clinical researchers, Journalists, citizen scientists, or anyone interested in reading and discovering research. Retrospective cohort study. Objectives: Progressive supranuclear palsy (PSP) is characterized by deposition of straight filament tau aggregates in the grey matter (GM) of deep nuclei and cerebellum. We conducted a systematic review and meta-analysis of studies comparing survival in clinically diagnosed DLB to AD. Sorry, you need to be a researcher to join ResearchGate. View John O'Brien’s profile on LinkedIn, the world’s largest professional community. This is a randomized controlled trial (N = 495) of ATT assessment and ATT installation intervention, compared with control (restricted ATT package). Presentation varies between patients and can vary over time within an individual. Previous studies have shown that the brain network architecture assessed by EEG is altered in AD patients com... Introduction To understand the nature of this relationship, we investigated the association between lCMB, amyloid load, perfusion, and metabolism. If you have an account, log in and check your preferences. Reduced synaptic density in progressive supranuclear palsy and corticobasal syndrome, revealed by [ 11 C]UCB-J PET. In the present case series, we studied five subjects with Parkinson’s disease dementia. We investigated how neuroinflammation relates to the localization of tau and TDP-43 pathology, and to the heterogeneity of clinical disease. Methods Objective: Neuropathologically, it is characterized by alpha-synuclein protein deposition with variable degree of concurrent Alzheimer pathology. Otherwise create an account now and then choose your preferred email format. We conducted a prospective longitudinal study of plasma cytokines during the Mild Cognitive Impairment (MCI) stage of Lewy body disease and Alzheimer’s disease, hypothesising that cytokine levels would decrease over time and that this would be correlated with decline in cognition. Since the publication of this article [1], it has come to the attention of the authors that information for one of the authors was not included in the competing interests section. The LADIS Study.” Int J Geriatr Psychiatry 21(10):983-9 Details, McKeith IG, Rowan E, Askew K, Naidu A, Allan L, Barnett N, Lett D, Mosimann UP, Burn D, O'Brien JT (2006), “More severe functional impairment in dementia with lewy bodies than Alzheimer disease is related to extrapyramidal motor dysfunction.” Am J Geriatr Psychiatry 14(7):582-8 Details, Molloy SA, Rowan EN, O'Brien JT, McKeith IG, Wesnes K, Burn DJ (2006), “Effect of levodopa on cognitive function in Parkinson's disease with and without dementia and dementia with Lewy bodies.” J Neurol Neurosurg Psychiatry 77(12):1323-8 Details, Mosimann UP, Rowan EN, Partington CE, Collerton D, Littlewood E, O'Brien JT, Burn DJ, McKeith IG (2006), “Characteristics of visual hallucinations in Parkinson disease dementia and dementia with lewy bodies.” Am J Geriatr Psychiatry 14(2):153-60 Details, O'Brien JT (2006), “NICE and anti-dementia drugs: a triumph of health economics over clinical wisdom?” Lancet Neurol 5(12):994-6 Details, O'Brien JT (2006), “Vascular cognitive impairment.” Am J Geriatr Psychiatry 14(9):724-33 Details, O'Brien JT (2006), “Depression and comorbidity.” Am J Geriatr Psychiatry 14(3):187-90 Details, O'Brien JT, Firbank MJ, Krishnan MS, van Straaten EC, van der Flier WM, Petrovic K, Pantoni L, Simoni M, Erkinjuntti T, Wallin A, Wahlund LO, Inzitari D, LADIS Group (2006), “White matter hyperintensities rather than lacunar infarcts are associated with depressive symptoms in older people: the LADIS study.” Am J Geriatr Psychiatry 14(10):834-41 Details, Pakrasi S, Thomas A, Mosimann UP, Cousins DA, Lett D, Burn DJ, O'Brien JT, McKeith IG (2006), “Cholinesterase inhibitors in advanced Dementia with Lewy bodies: increase or stop?” Int J Geriatr Psychiatry 21(8):719-21 Details, Thomas AJ, Hendriksen M, Piggott M, Ferrier IN, Perry E, Ince P, O'Brien JT (2006), “A study of the serotonin transporter in the prefrontal cortex in late-life depression and Alzheimer's disease with and without depression.” Neuropathol Appl Neurobiol 32(3):296-303 Details, Aarsland D, Perry R, Larsen JP, McKeith IG, O'Brien JT, Perry EK, Burn D, Ballard CG (2005), “Neuroleptic sensitivity in Parkinson's disease and parkinsonian dementias.” J Clin Psychiatry 66(5):633-7 Details, Burton EJ, McKeith IG, Burn DJ, O'Brien JT (2005), “Brain atrophy rates in Parkinson's disease with and without dementia using serial magnetic resonance imaging.” Mov Disord 20(12):1571-6 Details, Colloby SJ, Williams ED, Burn DJ, Lloyd JJ, McKeith IG, O'Brien JT (2005), “Progression of dopaminergic degeneration in dementia with Lewy bodies and Parkinson's disease with and without dementia assessed using 123I-FP-CIT SPECT.” Eur J Nucl Med Mol Imaging 32(10):1176-85 Details, Firbank MJ, Burn DJ, McKeith IG, O'Brien JT (2005), “Longitudinal study of cerebral blood flow SPECT in Parkinson's disease with dementia, and dementia with Lewy bodies.” Int J Geriatr Psychiatry 20(8):776-82 Details, Firbank MJ, Molloy S, McKeith IG, Burn DJ, O'Brien JT (2005), “Longitudinal change in 99mTcHMPAO cerebral perfusion SPECT in Parkinson's disease over one year.” J Neurol Neurosurg Psychiatry 76(10):1448-51 Details, Firbank MJ, O'Brien JT, Pakrasi S, Pantoni L, Simoni M, Erkinjuntti T, Wallin A, Wahlund LO, van Straaten I, Inzitari D (2005), “White matter hyperintensities and depression--preliminary results from the LADIS study.” Int J Geriatr Psychiatry 20(7):674-9 Details, McKeith IG, Dickson DW, Lowe J, Emre M, O'Brien JT, Feldman H, Cummings J, Duda JE, Lippa C, Perry EK, Aarsland D, Arai H, Ballard CG, Boeve B, Burn DJ, Costa D, Del Ser T, Dubois B, Galasko D, Gauthier S, Goetz CG, Gomez-Tortosa E, Halliday G, Hansen LA, Hardy J, Iwatsubo T, Kalaria RN, Kaufer D, Kenny RA, Korczyn A, Kosaka K, Lee VM, Lees A, Litvan I, Londos E, Lopez OL, Minoshima S, Mizuno Y, Molina JA, Mukaetova-Ladinska EB, Pasquier F, Perry RH, Schulz JB, Trojanowski JQ, Yamada M, Consortium on DLB (2005), “Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium.” Neurology 65(12):1863-72 Details, Minett TS, Dean JL, Firbank M, English P, O'Brien JT (2005), “Subjective memory complaints, white-matter lesions, depressive symptoms, and cognition in elderly patients.” Am J Geriatr Psychiatry 13(8):665-71 Details, Molloy S, McKeith IG, O'Brien JT, Burn DJ (2005), “The role of levodopa in the management of dementia with Lewy bodies.” J Neurol Neurosurg Psychiatry 76(9):1200-3 Details, Mosimann UP, Müri RM, Burn DJ, Felblinger J, O'Brien JT, McKeith IG (2005), “Saccadic eye movement changes in Parkinson's disease dementia and dementia with Lewy bodies.” Brain 128(Pt 6):1267-76 Details, O'Brien JT, Firbank MJ, Mosimann UP, Burn DJ, McKeith IG (2005), “Change in perfusion, hallucinations and fluctuations in consciousness in dementia with Lewy bodies.” Psychiatry Res 139(2):79-88 Details, Pakrasi S, O'Brien JT (2005), “Emission tomography in dementia.” Nucl Med Commun 26(3):189-96 Details, Porter RJ, Phipps AJ, Gallagher P, Scott A, Stevenson PS, O'Brien JT (2005), “Effects of acute tryptophan depletion on mood and cognitive functioning in older recovered depressed subjects.” Am J Geriatr Psychiatry 13(7):607-15 Details, Rasmussen LS, O'Brien JT, Silverstein JH, Johnson TW, Siersma VD, Canet J, Jolles J, Hanning CD, Kuipers HM, Abildstrom H, Papaioannou A, Raeder J, Yli-Hankala A, Sneyd JR, Munoz L, Moller JT, ISPOCD2 Investigators (2005), “Is peri-operative cortisol secretion related to post-operative cognitive dysfunction?” Acta Anaesthesiol Scand 49(9):1225-31 Details, Tam CW, Burton EJ, McKeith IG, Burn DJ, O'Brien JT (2005), “Temporal lobe atrophy on MRI in Parkinson disease with dementia: a comparison with Alzheimer disease and dementia with Lewy bodies.” Neurology 64(5):861-5 Details, Thomas AJ, Davis S, Morris C, Jackson E, Harrison R, O'Brien JT (2005), “Increase in interleukin-1beta in late-life depression.” Am J Psychiatry 162(1):175-7 Details, Ballard CG, Burton EJ, Barber R, Stephens S, Kenny RA, Kalaria RN, O'Brien JT (2004), “NINDS AIREN neuroimaging criteria do not distinguish stroke patients with and without dementia.” Neurology 63(6):983-8 Details, Ballard CG, Jacoby R, Del Ser T, Khan MN, Munoz DG, Holmes C, Nagy Z, Perry EK, Joachim C, Jaros E, O'Brien JT, Perry RH, McKeith IG (2004), “Neuropathological substrates of psychiatric symptoms in prospectively studied patients with autopsy-confirmed dementia with lewy bodies.” Am J Psychiatry 161(5):843-9 Details, Ballard CG, Thomas A, Fossey J, Lee L, Jacoby R, Lana MM, Bannister C, McShane R, Swann A, Juszczak E, O'Brien JT (2004), “A 3-month, randomized, placebo-controlled, neuroleptic discontinuation study in 100 people with dementia: the neuropsychiatric inventory median cutoff is a predictor of clinical outcome.” J Clin Psychiatry 65(1):114-9 Details, Ballmaier M, O'Brien JT, Burton EJ, Thompson PM, Rex DE, Narr KL, McKeith IG, DeLuca H, Toga AW (2004), “Comparing gray matter loss profiles between dementia with Lewy bodies and Alzheimer's disease using cortical pattern matching: diagnosis and gender effects.” Neuroimage 23(1):325-35 Details, Burton EJ, McKeith IG, Burn DJ, Williams ED, O'Brien JT (2004), “Cerebral atrophy in Parkinson's disease with and without dementia: a comparison with Alzheimer's disease, dementia with Lewy bodies and controls.” Brain 127(Pt 4):791-800 Details, Colloby SJ, O'Brien JT, Fenwick JD, Firbank MJ, Burn DJ, McKeith IG, Williams ED (2004), “The application of statistical parametric mapping to 123I-FP-CIT SPECT in dementia with Lewy bodies, Alzheimer's disease and Parkinson's disease.” Neuroimage 23(3):956-66 Details, Fernando MS, O'Brien JT, Perry RH, English P, Forster G, McMeekin W, Slade JY, Golkhar A, Matthews FE, Barber R, Kalaria RN, Ince PG, Neuropathology Group of MRC CFAS (2004), “Comparison of the pathology of cerebral white matter with post-mortem magnetic resonance imaging (MRI) in the elderly brain.” Neuropathol Appl Neurobiol 30(4):385-95 Details, Firbank MJ, Lloyd AJ, Ferrier N, O'Brien JT (2004), “A volumetric study of MRI signal hyperintensities in late-life depression.” Am J Geriatr Psychiatry 12(6):606-12 Details, Hendricksen M, Thomas AJ, Ferrier IN, Ince P, O'Brien JT (2004), “Neuropathological study of the dorsal raphe nuclei in late-life depression and Alzheimer's disease with and without depression.” Am J Psychiatry 161(6):1096-102 Details, Kenny RA, Shaw FE, O'Brien JT, Scheltens PH, Kalaria R, Ballard C (2004), “Carotid sinus syndrome is common in dementia with Lewy bodies and correlates with deep white matter lesions.” J Neurol Neurosurg Psychiatry 75(7):966-71 Details, Lloyd AJ, Ferrier IN, Barber R, Gholkar A, Young AH, O'Brien JT (2004), “Hippocampal volume change in depression: late- and early-onset illness compared.” Br J Psychiatry 184:488-95 Details, Mosimann UP, Mather G, Wesnes KA, O'Brien JT, Burn DJ, McKeith IG (2004), “Visual perception in Parkinson disease dementia and dementia with Lewy bodies.” Neurology 63(11):2091-6 Details, O'Brien JT, Colloby S, Fenwick J, Williams ED, Firbank M, Burn D, Aarsland D, McKeith IG (2004), “Dopamine transporter loss visualized with FP-CIT SPECT in the differential diagnosis of dementia with Lewy bodies.” Arch Neurol 61(6):919-25 Details, O'Brien JT, Lloyd A, McKeith I, Gholkar A, Ferrier N (2004), “A longitudinal study of hippocampal volume, cortisol levels, and cognition in older depressed subjects.” Am J Psychiatry 161(11):2081-90 Details, Paling SM, Williams ED, Barber R, Burton EJ, Crum WR, Fox NC, O'Brien JT (2004), “The application of serial MRI analysis techniques to the study of cerebral atrophy in late-onset dementia.” Med Image Anal 8(1):69-79 Details, Thomas AJ, Davis S, Ferrier IN, Kalaria RN, O'Brien JT (2004), “Elevation of cell adhesion molecule immunoreactivity in the anterior cingulate cortex in bipolar disorder.” Biol Psychiatry 55(6):652-5 Details, Thomas AJ, Kalaria RN, O'Brien JT (2004), “Depression and vascular disease: what is the relationship?” J Affect Disord 79(1-3):81-95 Details, Wiseman RM, Saxby BK, Burton EJ, Barber R, Ford GA, O'Brien JT (2004), “Hippocampal atrophy, whole brain volume, and white matter lesions in older hypertensive subjects.” Neurology 63(10):1892-7 Details, Almeida OP, Burton EJ, Ferrier N, McKeith IG, O'Brien JT (2003), “Depression with late onset is associated with right frontal lobe atrophy.” Psychol Med 33(4):675-81 Details, Almeida OP, Burton EJ, McKeith I, Gholkar A, Burn D, O'Brien JT (2003), “MRI study of caudate nucleus volume in Parkinson's disease with and without dementia with Lewy bodies and Alzheimer's disease.” Dement Geriatr Cogn Disord 16(2):57-63 Details, Burn DJ, O'Brien JT (2003), “Use of functional imaging in Parkinsonism and dementia.” Mov Disord 18 Suppl 6:S88-95 Details, Burn DJ, Rowan EN, Minett T, Sanders J, Myint P, Richardson J, Thomas A, Newby J, Reid J, O'Brien JT, McKeith IG (2003), “Extrapyramidal features in Parkinson's disease with and without dementia and dementia with Lewy bodies: A cross-sectional comparative study.” Mov Disord 18(8):884-9 Details, Cousins DA, Burton EJ, Burn D, Gholkar A, McKeith IG, O'Brien JT (2003), “Atrophy of the putamen in dementia with Lewy bodies but not Alzheimer's disease: an MRI study.” Neurology 61(9):1191-5 Details, Firbank MJ, Colloby SJ, Burn DJ, McKeith IG, O'Brien JT (2003), “Regional cerebral blood flow in Parkinson's disease with and without dementia.” Neuroimage 20(2):1309-19 Details, Firbank MJ, Minett T, O'Brien JT (2003), “Changes in DWI and MRS associated with white matter hyperintensities in elderly subjects.” Neurology 61(7):950-4 Details, Grace J, O'Brien JT (2003), “Association of life events and psychosocial factors with early but not late onset depression in the elderly: implications for possible differences in aetiology.” Int J Geriatr Psychiatry 18(6):473-8 Details, Karas GB, Burton EJ, Rombouts SA, van Schijndel RA, O'Brien JT, Scheltens Ph, McKeith IG, Williams D, Ballard C, Barkhof F (2003), “A comprehensive study of gray matter loss in patients with Alzheimer's disease using optimized voxel-based morphometry.” Neuroimage 18(4):895-907 Details, McKeith IG, Burn DJ, Ballard CG, Collerton D, Jaros E, Morris CM, McLaren A, Perry EK, Perry R, Piggott MA, O'Brien JT (2003), “Dementia with Lewy bodies.” Semin Clin Neuropsychiatry 8(1):46-57 Details, O'Brien JT, Erkinjuntti T, Reisberg B, Roman G, Sawada T, Pantoni L, Bowler JV, Ballard C, DeCarli C, Gorelick PB, Rockwood K, Burns A, Gauthier S, DeKosky ST (2003), “Vascular cognitive impairment.” Lancet Neurol 2(2):89-98 Details, O'Brien JT, Thomas A, English P, Perry R, Jaros E (2003), “A prospectively studied clinicopathological case of 'vascular depression'.” Int J Geriatr Psychiatry 18(7):656-7 Details, O'Brien KK, Saxby BK, Ballard CG, Grace J, Harrington F, Ford GA, O'Brien JT, Swan AG, Fairbairn AF, Wesnes K, del Ser T, Edwardson JA, Morris CM, McKeith IG (2003), “Regulation of attention and response to therapy in dementia by butyrylcholinesterase.” Pharmacogenetics 13(4):231-9 Details, Pakrasi S, Mukaetova-Ladinska EB, McKeith IG, O'Brien JT (2003), “Clinical predictors of response to Acetyl Cholinesterase Inhibitors: experience from routine clinical use in Newcastle.” Int J Geriatr Psychiatry 18(10):879-86 Details, Porter RJ, Lunn BS, O'Brien JT (2003), “Effects of acute tryptophan depletion on cognitive function in Alzheimer's disease and in the healthy elderly.” Psychol Med 33(1):41-9 Details, Thomas AJ, O'Brien JT, Barber R, McMeekin W, Perry R (2003), “A neuropathological study of periventricular white matter hyperintensities in major depression.” J Affect Disord 76(1-3):49-54 Details, Thomas AJ, Perry R, Kalaria RN, Oakley A, McMeekin W, O'Brien JT (2003), “Neuropathological evidence for ischemia in the white matter of the dorsolateral prefrontal cortex in late-life depression.” Int J Geriatr Psychiatry 18(1):7-13 Details, Ballard CG, O'Brien JT, Reichelt K, Perry EK (2002), “Aromatherapy as a safe and effective treatment for the management of agitation in severe dementia: the results of a double-blind, placebo-controlled trial with Melissa.” J Clin Psychiatry 63(7):553-8 Details, Burton EJ, Karas G, Paling SM, Barber R, Williams ED, Ballard CG, McKeith IG, Scheltens P, Barkhof F, O'Brien JT (2002), “Patterns of cerebral atrophy in dementia with Lewy bodies using voxel-based morphometry.” Neuroimage 17(2):618-30 Details, Colloby SJ, Fenwick JD, Williams ED, Paling SM, Lobotesis K, Ballard C, McKeith I, O'Brien JT (2002), “A comparison of (99m)Tc-HMPAO SPET changes in dementia with Lewy bodies and Alzheimer's disease using statistical parametric mapping.” Eur J Nucl Med Mol Imaging 29(5):615-22 Details, Davis S, Thomas A, Perry R, Oakley A, Kalaria RN, O'Brien JT (2002), “Glial fibrillary acidic protein in late life major depressive disorder: an immunocytochemical study.” J Neurol Neurosurg Psychiatry 73(5):556-60 Details, Firbank MJ, Harrison RM, O'Brien JT (2002), “A comprehensive review of proton magnetic resonance spectroscopy studies in dementia and Parkinson's disease.” Dement Geriatr Cogn Disord 14(2):64-76 Details, O'Brien JT, Wiseman R, Burton EJ, Barber B, Wesnes K, Saxby B, Ford GA (2002), “Cognitive associations of subcortical white matter lesions in older people.” Ann N Y Acad Sci 977:436-44 Details, Phipps AJ, O'Brien JT (2002), “Memory clinics and clinical governance--a UK perspective.” Int J Geriatr Psychiatry 17(12):1128-32 Details, Porter RJ, Barnett NA, Idey A, McGuckin EA, O'Brien JT (2002), “Effects of hydrocortisone administration on cognitive function in the elderly.” J Psychopharmacol 16(1):65-71 Details, Porter RJ, Marshall EF, O'Brien JT (2002), “Effects of rapid tryptophan depletion on salivary and plasma cortisol in Alzheimer's disease and the healthy elderly.” J Psychopharmacol 16(1):73-8 Details, Thomas AJ, Ferrier IN, Kalaria RN, Davis S, O'Brien JT (2002), “Cell adhesion molecule expression in the dorsolateral prefrontal cortex and anterior cingulate cortex in major depression in the elderly.” Br J Psychiatry 181:129-34 Details, Thomas AJ, O'Brien JT, Davis S, Ballard C, Barber R, Kalaria RN, Perry RH (2002), “Ischemic basis for deep white matter hyperintensities in major depression: a neuropathological study.” Arch Gen Psychiatry 59(9):785-92 Details, Thomas AJ, Perry R, Barber R, Kalaria RN, O'Brien JT (2002), “Pathologies and pathological mechanisms for white matter hyperintensities in depression.” Ann N Y Acad Sci 977:333-9 Details, Ballard CG, O'Brien JT, Swann AG, Thompson P, Neill D, McKeith IG (2001), “The natural history of psychosis and depression in dementia with Lewy bodies and Alzheimer's disease: persistence and new cases over 1 year of follow-up.” J Clin Psychiatry 62(1):46-9 Details, Barber R, McKeith IG, Ballard C, Gholkar A, O'Brien JT (2001), “A comparison of medial and lateral temporal lobe atrophy in dementia with Lewy bodies and Alzheimer's disease: magnetic resonance imaging volumetric study.” Dement Geriatr Cogn Disord 12(3):198-205 Details, Court JA, Ballard CG, Piggott MA, Johnson M, O'Brien JT, Holmes C, Cairns N, Lantos P, Perry RH, Jaros E, Perry EK (2001), “Visual hallucinations are associated with lower alpha bungarotoxin binding in dementia with Lewy bodies.” Pharmacol Biochem Behav 70(4):571-9 Details, Jackson EJ, Rajah S, Morris C, Ballard C, Thomas AJ, O'Brien JT (2001), “Is apolipoprotein e4 associated with cognitive decline in depression?” Int J Geriatr Psychiatry 16(4):436-7 Details, Kalaria RN, Ballard CG, Ince PG, Kenny RA, McKeith IG, Morris CM, O'Brien JT, Perry EK, Perry RH, Edwardson JA (2001), “Multiple substrates of late-onset dementia: implications for brain protection.” Novartis Found Symp 235:49-60; discussion 60-5 Details, Lloyd AJ, Grace JB, Jaros E, Perry RH, Fairbairn AF, Swann AG, O'Brien JT, McKeith IG (2001), “Depression in late life, cognitive decline and white matter pathology in two clinico-pathologically investigated cases.” Int J Geriatr Psychiatry 16(3):281-7 Details, Lobotesis K, Fenwick JD, Phipps A, Ryman A, Swann A, Ballard C, McKeith IG, O'Brien JT (2001), “Occipital hypoperfusion on SPECT in dementia with Lewy bodies but not AD.” Neurology 56(5):643-9 Details, Middelkoop HA, van der Flier WM, Burton EJ, Lloyd AJ, Paling S, Barber R, Ballard C, McKeith IG, O'Brien JT (2001), “Dementia with Lewy bodies and AD are not associated with occipital lobe atrophy on MRI.” Neurology 57(11):2117-20 Details, O'Brien JT, Ames D, Desmond P, Lichtenstein M, Binns D, Schweitzer I, Davis S, Tress B (2001), “Combined magnetic resonance imaging and single-photon emission tomography scanning in the discrimination of Alzheimer's disease from age-matched controls.” Int Psychogeriatr 13(2):149-61 Details, O'Brien JT, Ballard CG (2001), “Drugs for Alzheimer's disease.” BMJ 323(7305):123-4 Details, O'Brien JT, Paling S, Barber R, Williams ED, Ballard C, McKeith IG, Gholkar A, Crum WR, Rossor MN, Fox NC (2001), “Progressive brain atrophy on serial MRI in dementia with Lewy bodies, AD, and vascular dementia.” Neurology 56(10):1386-8 Details, Thomas AJ, Ferrier IN, Kalaria RN, Perry RH, Brown A, O'Brien JT (2001), “A neuropathological study of vascular factors in late-life depression.” J Neurol Neurosurg Psychiatry 70(1):83-7 Details, Barber R, Ballard C, McKeith IG, Gholkar A, O'Brien JT (2000), “MRI volumetric study of dementia with Lewy bodies: a comparison with AD and vascular dementia.” Neurology 54(6):1304-9 Details, Barber R, Gholkar A, Scheltens P, Ballard C, McKeith IG, O'Brien JT (2000), “MRI volumetric correlates of white matter lesions in dementia with Lewy bodies and Alzheimer's disease.” Int J Geriatr Psychiatry 15(10):911-6 Details, McKeith IG, Ballard CG, Perry RH, Ince PG, O'Brien JT, Neill D, Lowery K, Jaros E, Barber R, Thompson P, Swann A, Fairbairn AF, Perry EK (2000), “Prospective validation of consensus criteria for the diagnosis of dementia with Lewy bodies.” Neurology 54(5):1050-8 Details, O'Brien JT, Metcalfe S, Swann A, Hobson J, Jobst K, Ballard C, McKeith I, Gholkar A (2000), “Medial temporal lobe width on CT scanning in Alzheimer's disease: comparison with vascular dementia, depression and dementia with Lewy bodies.” Dement Geriatr Cogn Disord 11(2):114-8 Details, Porter RJ, Lunn BS, Walker LL, Gray JM, Ballard CG, O'Brien JT (2000), “Cognitive deficit induced by acute tryptophan depletion in patients with Alzheimer's disease.” Am J Psychiatry 157(4):638-40 Details, Thomas AJ, Ferrier IN, Kalaria RN, Woodward SA, Ballard C, Oakley A, Perry RH, O'Brien JT (2000), “Elevation in late-life depression of intercellular adhesion molecule-1 expression in the dorsolateral prefrontal cortex.” Am J Psychiatry 157(10):1682-4 Details, Walker MP, Ayre GA, Cummings JL, Wesnes K, McKeith IG, O'Brien JT, Ballard CG (2000), “The Clinician Assessment of Fluctuation and the One Day Fluctuation Assessment Scale.