2006;46:1005–10. Over the past two decades, there has been controversy regarding the possible link between the two disorders [1–6]. Essential tremor is the most common neurologic movement disorder, affecting 10 million people in the US . 2015; 5: 285. Multivariable Cox proportional hazards regression analysis was conducted for assessing the ET risk for the migraine cohort compared to the migraine-free cohort. PLoS One. Before releasing the LHID for the purpose of research, the NHRI eliminated the original identification information and encrypted an anonymous number for each individual in order to ensure privacy. Cephalalgia. Find out about Lean Library here, If you have access to journal via a society or associations, read the instructions below. When ET and migraine coexist their clinical phenotype and evolution remain almost unchanged. https://doi.org/10.1371/journal.pone.0173586.s001. For instance, a functional variant (Ser9Gly) of the dopamine D3 receptor (DRD3), although not confirmed in other studies, is associated with risk and age-at-onset of ET, the frequencies of the functional variant were found to be similar between ET patients with and without migraine . No association between essential tremor and migraine: A case-control study. No additional external funding was received for this study. Arguably, our findings are based on a population mainly composed of the Han ethnic group and thus may not be applied to Caucasian due to the genetic differences, as demonstrated by the conflicting results between the Chinese  and Italian  studies. https://doi.org/10.1371/journal.pone.0173586.t004. doi: 10.1371/journal.pone.0173586. Therefore, debate has been ongoing since the 1990s. To the best of our knowledge, this has not been done in previous studies. We investigated the frequency of migraine in patients with ET by enrolling 110 patients with ET and 110 age- and sex-matched healthy controls in a case-control study. Case reports have also been made of a familial disorder with migraine headaches, episodic vertigo, and essential tremor in affected family members. in a small study of patients with ET, 36.5% also had migraine. No, Is the Subject Area "Epidemiology" applicable to this article? Essential tremor (ET) and migraine headache are considered comorbid diseases on the basis of uncontrolled studies. Brain. Migraines are a misery for those who experience them. By contrast, Barbanti et al. eCollection 2017. Relative to the migraine-free cohort, the HRs of ET were 1.92 (95% CI = 1.52–2.41) and 1.71 (95% CI = 1.14–2.56) for female and male migraineurs respectively. The LHID consists of annual claims data including the beneficiary registries, prescriptions as well as all outpatient and inpatient records. Neuroimaging studies have shown widespread alterations in the cerebello-thalamo-cortical circuit [16, 17], with cerebellar involvement as the most consistent finding . The relationship between essential tremor (ET) and migraine was investigated in a prospective study. | -. The email address and/or password entered does not match our records, please check and try again. A value of 0.1 standardized mean difference or less indicates a negligible difference in means between two cohorts by using standardized mean difference . Table 2 shows the incidences and HRs of ET between the migraine and the migraine-free cohorts. This provides additional evidence to support the link between migraine and may suggest the presence of shared pathophysiology, whereby increasing the vulnerability of developing one condition with another. All applications are reviewed for approval of data release. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NLM He is the co-author of the new patient book Redefining Prostate Cancer, and is a contributing author on over 25 published studies. In a group of migraine patients, 17% had ET as compared to 1.2% of the control group. confidence interval; ET, J Neurol Neurosurg Psychiatry. No, PLOS is a nonprofit 501(c)(3) corporation, #C2354500, based in San Francisco, California, US, https://doi.org/10.1371/journal.pone.0173586. 10.1177/0333102409352253 The tremor can also be worsened by fatigue, cold, strong emotions, caffeine, low blood sugar, and some antidepressants. Data Availability: All relevant data are within the paper. In addition, migraine prophylaxis used by the individuals during the period of follow-up (including amitriptyline, clomipramine, duloxetine, flunarizine, fluoxetine, gabapentin, imipramine, paroxetine, sertraline, topiramate, valproate, venlafaxine and beta blockers) were also considered as confounding factors. revealed no significant difference in the frequency of lifetime migraine between 110 patients with ET and 110 matched controls . Higher prevalence of migraine in essential tremor: a case-control study. PLOS ONE promises fair, rigorous peer review, Essential tremor was diagnosed on the basis of a pos-tural and kinetic tremor without any other known causation. In an early cross-sectional study, Biary et al. PLoS ONE 12(3): Yes Please check you selected the correct society from the list and entered the user name and password you use to log in to your society website. These commonly used medications included anticonvulsants (valproate acid, topiramate and gabapentin ), selective serotonin re-uptake inhibitors (SSRIs) (fluoxetine, sertraline, paroxetine), serotonin norepinephrine reuptake inhibitors (SNRI) (venlafaxine, duloxetine) (Morgan and Sethi 2005)  , tricyclic antidepressant (amitriptyline, clomipramine and imipramine) , calcium channel blocker (flunarizine)  and beta blockers . College of Medicine, Taipei Medical University, Taipei, Taiwan, Affiliations At age 40, ET affects about 4% of the population. ET is estimated to have a prevalence of 0.3–4% in individuals ≥ 40 years old, with higher incidence of up to 14% in the elderly population . Cephalalgia. Cumulative incidence of subsequent essential…. Learn more. This cohort of subjects often consists of MA and chronic migraineurs who want to be reassured of the benign nature of their headaches as well as requesting for migraine prophylaxis. Similarly, other factors such as family history, symptoms and severities of ET were impossible to be examined. The data on the study population that were obtained from the NHIRD (http://nhird.nhri.org.tw/en/index.html) are maintained in the NHIRD (http://nhird.nhri.org.tw/). Some society journals require you to create a personal profile, then activate your society account, You are adding the following journals to your email alerts, Did you struggle to get access to this article? Competing Interests: The authors have declared that no competing interests exist. The migraine cohort had a higher proportion of use of migraine prophylaxis than the migraine-free cohort. A comorbidity of an individual is defined as having the comorbidity before the index date. Both migraine and essential tremor (ET) are common neurological disorders. Duval C, Norton L. Tremor in patients with migraine. In the subgroup analysis, patients with migraine were associated with higher risks of ET, regardless of gender, age or the existence of comorbidities. College of Medicine, China Medical University, Taichung, Taiwan, Affiliations If you have ever had a headache – and most people have at one time or another – you know how much head pain can make an ordinary day seem like slogging through a swamp. In the subgroup analysis, patients with migraine were associated with higher risks of ET, regardless of gender, age or the existence of comorbidities. Epub 2014 May 17. Department of Neurology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan, Funding: This study is supported in part by Taiwan Ministry of Health and Welfare Clinical Trial and Research Center of Excellence (MOHW105-TDU-B-212-133019), China Medical University Hospital, Academia Sinica Taiwan Biobank Stroke Biosignature Project (BM10501010037), NRPB Stroke Clinical Trial Consortium (MOST 105-2325-B-039-003), Tseng-Lien Lin Foundation, Taichung, Taiwan, Taiwan Brain Disease Foundation, Taipei, Taiwan, and Katsuzo and Kiyo Aoshima Memorial Funds, Japan; and CMU under the Aim for Top University Plan of the Ministry of Education, Taiwan. We found no significant differences in the frequency of lifetime and current migraine between patients and controls, even in patients stratified for age. Both migraine and essential tremor (ET) are common neurological disorders.